People

Piero Carninci, Ph.D.

Born and Educated in Italy he obtained his doctoral degree at the University of Trieste in 1989. From 1990 to 1995 he developed technologies for DNA extraction and DNA sequencing at Talent, a spin-off biotech.
He moved to Japan in 1995 at RIKEN, Tsukuba Life Science center and became tenure researcher in 1997. He has been developing technologies to capture full-length cDNAs, which were used for the construction of the FANTOM projects.
From 2008 he is a Team and Unit Leader and a Deputy Project Director at the RIKEN Omics Science Center in Yokohama. He has developed technologies to analyze the transcribed part of the genome (transcriptome), such as the cap-trapper and the CAGE. These technologies have been broadly used in the RIKEN FANTOM projects and allowed identifying non-coding RNAs as are the major output of the mammalian genome and providing comprehensive maps of the mammalian promoters. Additionally he developed a miniaturization of CAGE, in order to approach biological problems for which there is limited amount of starting material.
He has published more than 200 papers and book chapters, edited books and is a member of editorial boards of various scientific journals. He has an h index of 50.
E-mail: carninci@transsine.com

Stefano Gustincich, Ph.D.

Stefano Gustincich is co-founder of TransSINE Technologies and is associate professor at SISSA, Trieste (Italy), where he is the head of the laboratory of functional neurogenomics.
Stefano Gustincich obtained his PhD in Molecular Genetics & Biotechnology at SISSA, Trieste, Italy, studying genes involved in the negative control of cell proliferation. He was awarded a Long-term EMBO fellowship to work as a post-doctoral fellow at the department of Neurobiology at Harvard Medical School, Boston, USA. He developed a transgenic mouse model to study the function of dopaminergic neurons of the retina, a rare neuronal cell type involved in the control of light adaptation.
In 1998, he became Instructor in Neurobiology at Harvard Medical School where he developed techniques to study gene expression in single cells. He has been honoured with the career development award by The Giovanni Armenise-Harvard Foundation to join the Sector of Neurobiology at SISSA as a principal investigator.
Since 2005 he has been an Associate professor in Physiology at SISSA. His laboratory applies functional genomics techniques to study brain function in health and disease with special emphasis on the dopaminergic neurons of the Substantia Nigra and Parkinson’s disease.
In 2011 he was awarded the Italian national prize for Innovation in biotechnology.
He has published more than 60 papers with an h index of 24.
E-mail: gustincich@transsine.com

Claudio Santoro, M.D.

Claudio Santoro obtained his MD at University of Torino, Italy, in 1981, studying genes encoding human plasma proteins. From 1982 to 1985, he was post-doctoral fellow at the EMBL, Heidelberg, Germany, where he characterized the genes coding for several human plasma-proteins, including haptoglobin, retinol-binding protein and ferritins. From 1986 to 1988, he was a HHMI research fellow at the Department of Biochemistry, University of California at Berkeley, USA, where he developed in vitro methods to dissect RNApolII-dependent transcription complexes. Since then he has studied the transcriptional regulation of human globin genes and, lately, he has developed methods to characterize large antigenic and/or antibody repertoires.
In 2000, he became professor of Applied Biology at the University of Easter Piedmont “Amedeo Avogadro” in Novara, Italy. His lab is devoted to biomarker discovery in autoimmunity. He has published more than 50 papers.

Silvia Zucchelli, Ph.D.

Silvia Zucchelli is a member of TransSINE Technologies scientific staff. She was born in Milan (Italy) in 1971. She has more than 15 years experience in molecular biology, immunology and neuroscience. Dr. Zucchelli has a degree in Molecular Biology at the University of Milan and a Ph.D. in Immunology at the University of Rome.
She contributed to the development of a genetic-based vaccine against Hepatitis C Virus at IRBM-Merck Research Laboratories in Rome (Italy). Following a post-doctoral training at Joslin Diabetes Center at Harvard Medical School in Boston (USA), she joined the group of Prof. Stefano Gustincich in Trieste (Italy) to work on functional genomic of the brain. Dr. Zucchelli has more than 15 scientific publications on peer-reviewed journals, with an average impact factor of 9.369.
Since 2011 she is a member of the FANTOM 5 Consortium for the study of mammalian promotorome with focus on non-coding RNA and neurodegeneration.
E-mail: zucchelli@transsine.com